Jeff Carter scored two goals as the Flyers defeated the Blackhawks 4-1 in a rematch of last season's Stanley Cup Finals.
Philadelphia rookie Sergei Bobrovsky made 29 saves in net.
Bobrovsky, 22, lost a bid for his first career shutout at 6:49 of the third period when Marian Hossa scored on a penalty shot.
Defending Stanley Cup champion Chicago lost in regulation for the first time since Jan. 5 and had been on a 5-0-1 roll.
Flyers Top Blackhawks In Cup Rematch